Description

Tetramisole hcl powder CAS 5086-74-8 also known as Tetramisole hydrochloric, generally exists in the form of tetramisole hydrochloride powder, color, eye shadow powder appearance and character: white to milky white crystalline powder, veterinary medicine raw material. It is a white crystalline powder that can sometimes appear in a light yellow or purple color. Its appearance has a certain degree of transparency, and the crystal structure can be clearly seen. It has high solubility in water and can also be dissolved in ethanol and methanol. At room temperature, every 1 gram of Tetramisole Hydrochloride can be dissolved in 1ml of water. When this drug reacts with acids and bases, precipitation occurs. The refractive index is 1.583, which can be used for the detection and identification of this drug. When it is dissolved in water, its refractive index does not change much, which enables high-precision measurement and detection of the drug in experiments. Widely used veterinary and human drugs are used as antidotes and antiparasitic drugs.

Chemical Formula

C11H13ClN2S

Exact Mass

240

Molecular Weight

241

m/z

240 (100.0%), 242 (32.0%), 241 (11.9%), 242 (4.5%), 243 (3.8%), 244 (1.4%)

Elemental Analysis

C, 54.88; H, 5.44; Cl, 14.72; N, 11.64; S, 13.32

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Solubility:

Tetramisole hcl powder has good solubility and is easily soluble in polar solvents such as water, ethanol, chloroform, and benzene. Its solubility increases with temperature. Poor solubility in non-polar solvents such as petroleum ether.

Melting point:

The melting point of Tetramisole Hydrochloride is around 275 ℃.

Acid-base properties:

Tetramisole Hydrochloride is a highly alkaline compound whose amino functional groups can react with weak acids to form salts. In water, Tetramisole Hydrochloride undergoes hydrolysis reactions, generating free amino and electrophilic Tetramisole.

Stability:

Tetramisole Hydrochloride can be stored for several years without deterioration under dry and ventilated conditions. However, under sunlight or high temperature and humidity conditions, decomposition reactions can occur, leading to drug degradation and failure.

Oxidation-reduction properties:

Tetramisole Hydrochloride is a weak reducing agent with the ability to reduce iron ions. It can react with some oxidants, such as bromine water, iodine water, and perchloric acid.

The most commonly used method in the synthesis of tetramisole hcl powder  is the reaction of imidazole methyl acetate and 2-chloropropionyl chloride. The following will provide a detailed introduction to all the synthesis methods of Tetramisole Hydrochloride.

The first method is the reaction of imidazole methyl acetate with 2-chloropropionyl chloride, which is one of the most commonly used methods in TH synthesis.

The process is as follows:

Firstly, dissolve methyl imidazole acetate and 2-chloropropionyl chloride in anhydrous dimethylformamide (DMF), respectively. Slowly mix the two solutions and stir for 10 to 20 hours. The reaction product is the precursor of TH -2-chloro-N, N, 2-trimethylacetylimidazole (2-Cl-MH), which can be further reacted to prepare TH after separation and purification of 2-Cl-MH. Finally, add a dilute hydrochloric acid (HCl) aqueous solution to obtain TH.

The second method is to react with imidazolacetone and crotonic acid:

The main step of this method is to prepare a precursor of 2-amino-2-methyl-1-propanol (AMP) through a reduction reaction in the presence of imidazolacetone and crotonic acid; Subsequently, AMP was subjected to sulfonylation reaction to obtain TH.

The following is a detailed description of all uses of Tetramisole hcl powder:

Animal use:

Tetramisole Hydrochloride can be used to treat cordyceps infection in animals. Cordyceps is a fungus that can infect various mammals. Cordyceps infection can lead to weight loss, anemia, and other health problems. Tetramisole Hydrochloride can help control cordyceps infection and promote animal health.

Animal husbandry:

Tetramisole Hydrochloride can be used in animal husbandry to prevent and treat roundworm infections. Ascaris infection is a common animal parasitic infection that can lead to increased production costs in animal husbandry and animal health issues. Tetramisole Hydrochloride can control roundworm infection and improve livestock production efficiency.

Poultry:

Tetramisole Hydrochloride can be used to prevent and treat small nematode infections in poultry. Small nematode infection is a common parasitic infection in poultry, which can lead to decreased production performance and reduced feed conversion rate. Tetramisole Hydrochloride can control small nematode infections and improve poultry production efficiency.

In 1964

A researcher named Wright from ITRI (British Industrial Research Institute) discovered some new sulfuryl compounds while searching for new drug synthesis methods. Among them, 4-phenyl-2,3,5,6-tetrahydro-1H-pyrazole (THCP) has achieved excellent anti infective activity against the majority of the main intestinal parasite, Helicobacter.

the medical field is conducting extensive research and experiments on THCP, which is expected to be used to treat human parasitic infections. Research has shown that THCP has no significant therapeutic effect on human intestinal parasites, but its cocaine associated compound has been proven to be an effective anti intestinal parasite drug.

began to improve the structure of 4-phenyl-2,3,5,6-tetrahydro-1H-pyrazole in search of better antibacterial activity. After a long period of research, researchers ultimately transformed THCP into THFA, which has stronger anti parasite activity. At the same time, the solubility of Tetramisole Hydrochloride has also been significantly improved.

In 1965

Tetramisole Hydrochloride was first marketed as a drug for treating intestinal ileitis. Then, Tetramisole Hydrochloride is widely used to treat various diseases such as roundworm disease, canine parvovirus disease, hookworm disease, and some parasitic infections.

By 2021

Over time, Tetramisole Hydrochloride has gradually become a widely used drug for the diagnosis and treatment of canine infections and certain human diseases. Tetramisole Hydrochloride is considered one of the top choice drugs for treating parasitic infections.

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