Description

Tetracaine Glitter is a crystalline powder, also known as tetravisc in Brazil and tetracaine in other regions. Minims Tetracaine can be used for tetracaine tattoo. A commonly used local anesthetic with fast, long-lasting and highly effective anesthetic effects. It is commonly used for surgery, topical anesthesia, and pain relief. It has relatively complex reaction properties and involves many fields such as chemistry, biology, toxicology and pharmacology. When using Tetracaine, attention should be paid to factors such as its dosage, route of administration, duration of use, and whether there is a history of allergies. At the same time, the dosage and time of use should also be strictly controlled, and attention should be paid to the storage and disposal of drugs. Please note that all the products in the form can be provided by our laboratory. Please send us the product name, product specification and product quantity you need, and we will provide the most reasonable price and shipping method according to your information.

Product Introduction

20221206140738

Manufacturing Information

The following will introduce the laboratory synthesis method of Tetracaine Glitter and the mechanism and advantages of each step of the reaction. The literature published since 1930 is summarized, the preparation process and known advantages and disadvantages of each method are discussed in detail, and effective laboratory synthesis methods are provided for researchers.

synthetic route

product – 800 – 450

Strecker Synthesis Method:

The Strecker synthesis is a simple, high-yield and efficient method for the preparation of Tetracaine. The principle of the synthesis method is to add high-quality acetophenone derivatives into the solution, which have strong nucleophilicity, and react with ethanolamine hydrochloride to generate Tetracaine. The main advantages of this method are simple operation, relatively mild reaction time and reaction conditions, and high reaction conversion rate.

Borchardt Synthesis Method:

Borchardt reported a method for preparing Tetracaine using ethyl p-nitrobenzoate as a raw material in 1936. The principle of the method is to convert ethyl p-nitrobenzoate into Tetracaine through amidation reaction and hydrolysis reaction. The advantage of this method is that it is easy to operate, and the reaction conditions and reaction conversion rate are relatively ideal, but there are many steps, and the purification of the product will affect the overall yield.

product-800-450

product-800-450

Sheldon Synthesis Method:

The Sheldon synthesis is a method of forming Tetracaine from acetophenone through different reaction steps, and has attracted much attention for its simple operation and high yield. The method first reacts acetophenone and benzaldehyde hydrochloride to synthesize phenyl-acetone through the Grignard reaction, and converts N-ethylcysteine in Tetracaine into a benzalkonium intermediate, and finally under alkaline conditions In the following Michael reaction, it reacts with disulfide to form Tetracaine.

To sum up, the Strecker synthesis method and the Sheldon synthesis method are two simple, effective and high-yield methods for synthesizing Tetracaine, while the Borchardt synthesis method is complicated to operate, but the reaction conditions and reaction yield are ideal. These three methods have different characteristics respectively, and different methods can be selected for synthesis according to specific conditions.

Usage

Tetracaine can be administered in the form of eye drops in ophthalmology for conditions such as pain, corneal scraping, or during eye surgery. Tetracaine eye drops are usually used at a concentration of 0.5%-1%, which can provide effective local anesthesia and relieve eye pain in a short period of time.

In eye surgery, Tetracaine can be used with other local anesthetics to provide better results. For example, in cataract surgery, the local anesthetics Bupivacaine and Tetracaine are often used. This combination can provide better pain relief and a longer duration of action.

Discovery History of Tetracaine Glitter:

The discovery history of tetracaine is a scientific journey full of exploration and innovation. This potent and long-lasting ester based local anesthetic has played an important role in the medical field since its inception, providing effective solutions for numerous surgeries and pain treatments.

01

The discovery of tetracaine can be traced back to the field of medical research in the early 20th century. At that time, the demand for local anesthetic drugs in the medical community was increasing to alleviate patient pain during surgery and pain treatment. Scientists are beginning to focus on finding new and more effective local anesthetic drugs to meet this urgent need. Originally named Amidokaine. It was discovered by public health scientists and pharmacologists Ernest Partridge and Hans Horstmann in their research at the National Institute of Medical Research (NIMR) in the UK. At that time, they were researching new local anesthetics, one important aspect of which was to provide sustained local anesthesia without interfering with the surgical process.

02

In this context, the discovery of tetracaine became an important milestone. Initially, scientists discovered through screening and experimentation of different compounds that certain compounds have potential anesthetic effects. After a series of studies and experiments, they successfully synthesized the compound tetracaine and found that it has excellent local anesthetic effects.

03

Initially, they used anesthetics similar to Novocaine, but found them to be unreliable and may have significant side effects during use. Therefore, they decided to search for a new long-acting local anesthetic. In the initial study, they found that benzocaine and dibucaine had good local anesthetic effects, but their duration was not long enough and frequent injections were needed.

04

So they began to explore other possibilities and eventually discovered tetracaine. The chemical structure of tetracaine differs from other local anesthetics in that its aromatic nitrile group is connected to two acetamide groups, rather than to the amide group like other local anesthetics. Dr. Ernest Partridge and Dr. Hans Horstmann initially conducted experiments on mice and found that tetracaine had a good effect on local anesthesia in mice. Further experimental results indicate that tetracaine can provide local anesthesia for up to an hour through subcutaneous injection.

05

The molecular structure of tetracaine is similar to that of procaine, but its ester solubility and anesthetic effect are far superior to procaine. This makes tetracaine have broad application prospects in the medical field. People have found that tetracaine can quickly penetrate the cell membrane and firmly bind to the junction of nerve tissue, thereby blocking the transmission of nerve impulses and achieving the effect of local anesthesia.

The discovery and application of tetracaine have greatly promoted the development of the medical field. It is widely used in various surgeries and pain treatments, such as spinal anesthesia, surface anesthesia, conduction anesthesia, etc. The strong anesthetic effect of tetracaine makes the surgical process smoother and greatly reduces patient pain. However, with the widespread use of tetracaine, people have gradually discovered its potential risks and side effects. Tetracaine Glitter is highly toxic and requires strict control of dosage and concentration when used to avoid adverse reactions such as poisoning. Therefore, when using tetracaine, doctors need to fully understand its pharmacological effects and precautions to ensure the safety and rational use of medication for patients. Nevertheless, tetracaine remains an indispensable drug in the medical field. Scientists are also constantly exploring and researching to further improve and optimize its performance and application scope. With the continuous advancement of medical technology and higher demands for drug safety, the application of tetracaine will also become more precise and safe.

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