Description

Procaine hydrochloride CAS 51-05-8 can be used as a raw material, chemical material in the laboratory. it is a relatively stable salt, usually a white crystalline powder or colorless transparent crystal. Its color is usually influenced by chemical purity and production processes. The solubility in water is quite high. It can also be dissolved or dispersed in some organic solvents, such as ethanol, ether, chloroform, and benzene. The melting point of is 154-158 ℃. This melting point can be used as one of the standards for detecting its quality. It is a relatively stable anesthetic. It can be stably stored at room temperature. It can also resist oxidation in the air and is not affected by light.

Chemical Formula

C13H21ClN2O2

Exact Mass

272.13

Molecular Weight

272.77

m/z

272.13 (100.0%), 274.13 (32.0%), 273.13 (14.1%), 275.13 (4.5%)

Elemental Analysis

C, 57.24; H, 7.76; Cl, 13.00; N, 10.27; O, 11.73.

It is a local anesthetic and is also used as an over-the-counter medication to relieve mild pain, such as toothache. It is widely used in the medical industry because it is a safe and effective local anesthetic. Here we will discuss several methods for synthesizing procaine hydrochloride.
1. Reactions between Para aminobenzoic acid (PABA) and diethylamine ether

The earliest preparation method of product was to react PABA and diethylamine to form procaine under alkaline conditions. This method was discovered by Ernest Fourneau and Pierre Refrain in 1905.

Firstly, PABA is acidified with concentrated sulfuric acid to form the corresponding amide, and then it reacts with ethylenediamine under the action of sodium hydroxide to form a procaine base. Finally, the procaine base is neutralized with hydrochloric acid solution to obtain product.
2. Reaction between Procainamide and PABA

Procainamide is an advanced psychotropic drug obtained by sulfonation reaction of procaine. Therefore, procaine reacts with p-Toluene sulfonic acid and H2SO4 to produce procaine mide methylated at position 14, and reacts with PABA to produce HCL salt.

Pure API (Active pharmaceutical ingredient) for science researching only, Standard substance for analysis, Pharmacokinetic study, receptor resistance test etc. Procaine hydrochloride, white crystalline or crystalline powder is local anesthetic with strong effect but less toxicity and short time-effective. Clinical practice mainly uses procaine hcl, procaine hcl powder for infiltration anesthesia and conduction anesthesia. Because of its poor penetration, it is generally not used for surface anesthesia.

Chemical property:

(a) Stability:

Procaine hydrochloride can be stably stored at room temperature and pressure. However, it will change color, decompose, and lose its characteristics in sunlight and air.

(b) Solubility:

It is easily soluble in water and has extremely low volatility. It can also be soluble in some organic solvents such as methanol and ethanol. When the solubility is 25 ℃, there is 8.8g of product in every 100ml of water.

(c) PH value:

The aqueous solution ofit is weakly acidic, with a pH value of approximately 3.0-5.0.

(d) Oxidation-reduction properties:

It appears blue in the presence of cations such as Fe3+and Cu2+. It can also be oxidized by reagents such as HI, HNO3, FeCl3 trachoma reagent, Molisch reagent, etc., and heated under alkaline conditions to form a purple substance.

(e) Dilution:

The dilution of product solution gradually increases, but it cannot decompose.

(f) Alkalinity:

It is weakly acidic and can decompose into hydrogen ions and stable hydrochloric acid molecules with equal moles.

(g) Instability:

It has strict requirements for stability. It must be stored in a sealed, moisture-proof, and light proof environment, and avoid contact with alkaline solvents, metal ions, and oxidants.

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