Description

Lidocaine hydrochloride powder is mainly characterized by its easy penetration into the mucosa, so it is often used on the mucosal surface, and can also be used for intraspinal block and nerve block. Lidocaine Hydrolide, Molecular formula: C14H22N2O · HCl, CAS 73-78-9, molecular weight: 270.8 g/mol. It is a white crystalline powder with no odor or slight special odor. At room temperature, the solubility in water is high, about 50 mg/mL, and it can also be dissolved in polar organic solvents such as ethanol, acetone and methanol, but it is low in non-polar solvents such as Petroleum ether, chloroform and dichloromethane. The form of hydrochloride is acidic, and its aqueous solution is in the acidic pH range. The pH value is usually between 4.0 and 5.5, depending on the solution concentration and temperature. Its terminal drugs can be used as surface anesthetics, non blocking local anesthetics, and arrhythmia treatment drugs, but the specific use needs to be determined according to the specific situation. However, please note that the products produced by Shaanxi Achieve chem-tech Co.,Ltd are primary chemicals and are only used for scientific research purposes. Other uses are prohibited.

CF

C14H23ClN2O

EM

264

MW

270.8

m/z

264 (100.0%), 265 (16.2%), 266 (1.2%)

EA

C, 68.15; H, 9.15; N, 10.60; O, 12.10

Addition information:

Melting point 149 ° C, Density 1.1279 (rough estimate), Refractive index 1.5200 (estimated), Storage conditions 2-8 ° C, Solubility:solublesoluble 40 parts of solvent, Morphological neat.

This compound is composed of several important structural units, each responsible for different pharmacological activities and functions.

Benzene ring structure:

The molecule of lidocaine hydrochloride powder contains an aromatic benzene ring structure. The benzene ring is a six membered ring structure with strong stability and Conjugated system. This benzene ring structure plays a role in transferring Electronic effect, enhancing stability and providing steric hindrance in the molecule of Lidocaine Hydrochloride.

Amino structure:

The molecule of Lidocaine Hydrochloride contains two amino groups. One of the amino groups is located on the benzene ring and is called an aromatic amino group. The other amino group is located on the amide group and is called the amide amino group. The amino structure plays an important role in drug molecules, as it can form hydrogen bonds with other molecules and bind to receptors or ligands.

Amide group:

The molecule of Lidocaine Hydrochloride contains an amide group, consisting of a carbon atom and an oxygen atom. The amide group is one of the key components of the pharmacological activity of Lidocaine Hydrochloride, which inhibits the conduction of nerve impulses by interacting with sodium channels in nerve cells.

Lidocaine hydrochloride powder, Strong effect, strong penetration, fast. Used for various anesthesia, but also for the treatment of arrhythmia. Can also be used in patients with status epilepticus other anticonvulsant drugs ineffective.

Sodium channel blockade effect: Lidocaine Hydrochloride blocks the conduction of nerve impulses by binding to sodium channels on the nerve cell membrane and inhibiting their activity. It delays the formation and propagation of nerve impulses by preventing sodium ions from entering nerve cells. This sodium channel blockade prevents pain signals from being transmitted to the brain, thus achieving local anesthesia effects.

Lidocaine hydrochloride is a drug with multiple medical uses, mainly including the following aspects

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We offer a variety of transmission components

Local anesthesia:

Lidocaine hydrochloride is a local anesthetic with good tissue penetration and diffusion, which can achieve analgesic and anesthetic effects by reducing the sensitivity of nerve endings. It is suitable for various local anesthetics, such as infiltration anesthesia, epidural anesthesia, surface anesthesia, and nerve conduction block, and can be used to alleviate pain caused by tissue damage during surgery.

Anti arrhythmic effects:

Lidocaine hydrochloride has an anti arrhythmic effect, which can block the sodium ion channels of the heart, reduce autonomy and conductivity, prolong refractory period, and treat arrhythmias such as ventricular premature beats and ventricular tachycardia after acute myocardial infarction. In addition, it can also be used for digitalis poisoning, ventricular arrhythmias caused by cardiac surgery, and cardiac catheterization.

Central nervous system inhibition:

Lidocaine hydrochloride is a non depolarizing neuromuscular blocker that can enhance γ- The opening of chloride channels mediated by aminobutyric acid type A receptors causes a large amount of chloride ions to flow in and hyperpolarize neuronal cell membranes, leading to inhibition of the central nervous system. Therefore, it can be used for general anesthesia induction or adjuvant medication.

Muscle relaxation:

Lidocaine hydrochloride can increase the permeability of the presynaptic membrane to calcium ions, promote calcium ion influx, thereby promoting the synthesis and release of acetylcholine, enhancing the neurotoxicity of Ach, leading to weakened or stopped muscle contraction, and having a certain muscle relaxation effect.

We are the manufacturer of tetracaine. We have equipped professional laboratories and scientific researchers to complete the experiment, so as to maximize the yield and reduce the waste of resources and materials.

Lidocaine Hydrochloride is a common chemical that can be synthesized in the laboratory through various methods. Here is a basic synthesis route.

Raw material preparation:

-2,6-dimethylaniline is used as the starting material.

-Ethyl acetoacetate is used as ketone substrate.

-Chloroacetic acid is used as an acylation reagent.

-Ammonium hydroxide is used as a decarboxylation reagent.

-Sodium hydroxide is used as neutralization reagent.

-Hydrochloric acid is used as a crystallization reagent.

Reaction steps:

Here is a brief description of the main synthesis steps of Lidocaine Hydrochloride. The specific reaction conditions and operational details can be sent to us via email:

1. Acylation: 2,6-xylidine is reacted with Ethyl acetoacetate under alkaline conditions to produce N – Acetyl group -2,6-xylidine.
2. Decarboxylation: Decarboxylation is carried out for N-nenenebb acetyl -2,6-dimethylaniline. Ammonia is generally used as the decarboxylation reagent to generate N-acetyl-2,6-dimethylaniline.
3. Carboxylation reaction: N-acetyl-2,6-dimethylaniline is reacted with chloroacetic acid under alkaline conditions to produce an intermediate of Lidocaine (Lidocaine).
4. Hydrochloride formation: the final product of Lidocaine hydrochloride is produced by reacting hydrochloric acid with Lidocaine intermediate.
5. Crystallization purification: The reaction product is purified by crystallization, and the commonly used solvents are water and alcohols. Through appropriate crystallization conditions, high-purity Lidocaine Hydrochloride can be obtained.

It should be noted that the process of synthesizing lidocaine hydrochloride powderrequires strict control of reaction conditions and operating steps to ensure the purity and quality of the product. During the synthesis process, it is also necessary to comply with relevant safety operating regulations to ensure the safety of experimental personnel.

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