Description

Benzocaine, also known as ethyl p-aminobenzoate, is a local anesthetic belonging to the ester group of anesthetics. It is a white, crystalline powder with a slight odor and a bitter taste. Benzocaine is widely used in various medical and consumer products due to its ability to numb or desensitize the skin or mucous membranes upon topical application.

 

The term “200 mesh” refers to the particle size distribution of benzocaine powder. Mesh size is a measure of the particle size range through which a material can pass or be retained on a screen with specified openings. A higher mesh number indicates smaller particle sizes. Therefore, benzocaine 200 mesh signifies that the benzocaine powder has been processed to a fine, uniform particle size, with the majority of particles passing through a sieve with 200 openings per inch.

 

This fine particle size is advantageous for several reasons. Firstly, it enhances the solubility and dispersion of benzocaine, allowing for more efficient and even distribution on the skin or mucous membranes. Secondly, smaller particles tend to have a larger surface area, which can improve the speed and effectiveness of absorption, resulting in faster onset of anesthesia. Lastly, the fine powder is easier to handle and mix into formulations, making it ideal for use in a wide range of products, including topical creams, ointments, sprays, and even dental gels.

 

In summary, benzocaine 200 mesh is a finely processed form of benzocaine powder with improved solubility, dispersion, and absorption properties, making it a popular choice for use in medical and consumer products requiring local anesthesia.

 

Chemical Formula

C9H11NO2

Exact Mass

165.08

Molecular Weight

165.19

m/z

165.08 (100.0%), 166.08 (9.7%)

Elemental Analysis

C, 65.44; H, 6.71; N, 8.48; O, 19.37.

Benzocaine 200 mesh, a finely milled form of the local anesthetic agent benzocaine, finds diverse applications across various industries and medical practices. Its fine mesh size (200 mesh, typically referring to a particle size range of approximately 75 microns or less) allows for better dispersion, faster dissolution, and increased surface area for absorption, making it particularly suitable for the following applications:

Dental Care

It is commonly used in dental products such as gels, ointments, and mouthwashes for the temporary relief of sore gums, mouth irritation, and minor dental pain. Its fine particle size ensures rapid onset of anesthesia, providing quick relief to patients during and after dental procedures.

 

Topical Analgesics

In over-the-counter (OTC) topical creams, ointments, and sprays for pain relief, it helps to numb the skin, reducing discomfort associated with minor cuts, burns, insect bites, and sunburns. The fine mesh enhances penetration and distribution, allowing for more effective pain management.

 

Hemorrhoid Treatments

Benzocaine is also incorporated into hemorrhoid creams and suppositories in its 200-mesh form to provide temporary relief from the discomfort and itching caused by hemorrhoids. Its rapid absorption and onset of action make it a valuable component in these products.

 

Pharmaceutical Manufacturing

In the pharmaceutical industry, it serves as a raw material for the production of various medications requiring local anesthesia. Its fine particle size facilitates uniform blending and ensures consistent dosage in final products.

 

Cosmetic and Personal Care

Although less common, it may also find niche applications in certain cosmetic and personal care products, particularly those designed for sensitive skin or requiring a soothing effect. Its ability to reduce irritation and discomfort can be beneficial in these formulations.

 

Veterinary Medicine

For veterinary use, it can be incorporated into topical treatments for pets, providing pain relief during grooming procedures, wound care, or other minor medical interventions.

 

Benzocaine 200mesh CAS 94-09-7 Applications | Shaanxi BLOOM Tech Co., Ltd

It’s important to note that benzocaine, like any medication, should be used with caution and under the guidance of a healthcare professional. Excessive use or misuse can lead to adverse effects, including methemoglobinemia, a potentially serious condition that affects the body’s ability to carry oxygen in the blood.

 

01/

Methemoglobinemia: Benzocaine has been reported to cause acquired methemoglobinemia, a condition in which an abnormal form of hemoglobin, methemoglobin, accumulates in the blood. This can result in a decrease in the blood’s ability to carry oxygen, leading to symptoms such as cyanosis (blue discoloration of the skin and mucous membranes), shortness of breath, fatigue, and in severe cases, organ damage or even death. The incidence of benzocaine-induced methemoglobinemia can vary, but it is considered a rare event.

 

02/

Allergic Reactions: Some individuals may experience allergic reactions to Benzocaine, including skin rashes, itching, swelling, and in severe cases, anaphylaxis (a life-threatening allergic reaction).

 

03/

Local Irritation: Topical application of Benzocaine can cause local irritation, redness, burning, or stinging sensations at the site of application.

 

04/

Systemic Absorption: While Benzocaine is intended for topical use, it can be absorbed through the skin to some extent. Systemic absorption of Benzocaine, especially in large doses or over prolonged periods, may increase the risk of adverse effects.

 

05/

Drug Interactions: Benzocaine may interact with other medications, including some over-the-counter and prescription drugs. It is important to inform healthcare providers of all medications being taken, including topical anesthetics, to avoid potential interactions.

 

06/

Mutagenicity and Carcinogenicity: While not definitively proven, there are some concerns regarding the mutagenic and carcinogenic potential of Benzocaine. Long-term or excessive use should be avoided, especially in individuals with a history of skin cancer or other risk factors.

 

Ethanolamine method

The method relates to the esterification reaction between p – Ethanolamine and p-nitrobenzoic acid. The specific steps are as follows:

 

C6H5NO3+C2H7NO → C9H11NO2+H2O

 

Step 1: Prepare reactants

-P-Nitrobenzoic acid (C6H5NO3)

-Ethanolamine (C2H7NO)

 

Step 2: Reaction

Add p-nitrobenzoic acid and Ethanolamine in a dry Round-bottom flask with a molar ratio of 1:1.

Add a small pinch of alkaline catalyst, such as sodium carbonate (Na2CO3) or potassium carbonate (K2CO3), to the reaction bottle to promote the esterification reaction.

Stir the reaction mixture thoroughly at room temperature until the reaction is complete.

 

Step 3: Product extraction

Pour the reaction mixture into a Separatory funnel.

Add an appropriate amount of saturated saline solution and gently shake the Separatory funnel to extract Benzocaine into the aqueous phase.

Collect the aqueous phase into a clean beaker or container.

 

Step 4: Crystallization

Under appropriate temperature conditions, such as through an ice bath or heating, evaporate the solvent in the aqueous phase to obtain the crystallization of Benzocaine.

Filter out the crystals and wash them with appropriate solvents, such as cold water or cold ethanol.

Dry the washed crystals or use appropriate methods to obtain pure Benzocaine.

 

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